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Ontamalimab - Takeda

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Drug Profile

Ontamalimab - Takeda

Alternative Names: PF-00547659; PF-547659; SHP-647; TAK-647

Latest Information Update: 28 Jul 2026

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At a glance

  • Originator Pfizer
  • Developer Takeda
  • Class Anti-inflammatories; Hepatoprotectants; Monoclonal antibodies
  • Mechanism of Action Inflammation mediator inhibitors; MADCAM1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ulcerative colitis; Crohn's disease
  • New Molecular Entity Yes

Highest Development Phases

  • No development reported Non-alcoholic steatohepatitis
  • Discontinued Crohn's disease; Ulcerative colitis

Most Recent Events

  • 28 Jul 2026 No recent reports of development identified for phase-I development in Non-alcoholic-steatohepatitis in Unknown (SC)
  • 28 Feb 2026 No recent reports of development identified for phase-I development in Non-alcoholic-steatohepatitis in USA (SC)
  • 06 Jul 2025 Takeda terminates a phase-I clinical trials in Non-alcoholic steatohepatitis in USA due to strategic shift and reprioritization of clinical programs (SC) (NCT07052682)

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