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Drug Profile

Nepicastat oral- Asieris Pharmaceuticals

Alternative Names: APL-1401; DBH inhibitor programme; DβH inhibitor programme; Nepicastat hydrochloride; SYN-117

Latest Information Update: 07 Oct 2024

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At a glance

  • Originator Roche
  • Developer Asieris Pharmaceuticals; Biotie Therapies Corp.
  • Class Anti-inflammatories; Antineoplastics; Antiparkinsonians; Anxiolytics; Drug withdrawal therapies; Imidazoles; Neuropsychotherapeutics; Small molecules; Thiones
  • Mechanism of Action Dopamine beta-hydroxylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase I Ulcerative colitis
  • Discontinued Autoimmune disorders; Cancer; Cocaine-related disorders; Parkinson's disease; Post-traumatic stress disorders

Most Recent Events

  • 07 Oct 2024 Phase-I clinical trials in Ulcerative colitis in China (PO) (Asieris Pharmaceuticals Pipeline, October 2024)
  • 21 Sep 2023 Discontinued for Autoimmune disorders in China (PO) (Asieris pharmaceuticals pipeline, September 2023)
  • 30 Aug 2022 Nepicastat licensed to Asieris Pharmaceuticals for non-psychiatric indications

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