Crizotinib - Pfizer

Drug Profile

Crizotinib - Pfizer

Alternative Names: PF-002341066; PF-02341066; PF-1066; PF-2341066; Xalkori

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator Pfizer
  • Developer Astellas Pharma; Children's Oncology Group; Dana-Farber Cancer Institute; National Cancer Institute (USA); OxOnc Development; Pfizer; University of Colorado at Denver; University of Milan Bicocca
  • Class Antineoplastics; Chlorobenzenes; Fluorobenzenes; Piperidines; Pyrazoles; Pyridines; Small molecules
  • Mechanism of Action Anaplastic lymphoma kinase inhibitors; Proto oncogene protein c met inhibitors; ROS1-protein-inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • Phase II Bladder cancer; Non-Hodgkin's lymphoma; Renal cell carcinoma
  • Phase I/II Anaplastic large cell lymphoma; Neuroblastoma; Solid tumours
  • Phase I Glioblastoma; Prostate cancer

Most Recent Events

  • 24 Jun 2018 Biomarkers information updated
  • 29 May 2018 Crizotinib - Pfizer receives Breakthrough Therapy status for Anaplastic large cell lymphoma (Second-line therapy or greater) in USA
  • 29 May 2018 Crizotinib - Pfizer receives Breakthrough Therapy status for Non-small cell lung cancer (Metastatic disease, Second-line therapy or greater) in USA
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