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Drug Profile


Alternative Names: CRx-197; CRx-197 high dose topical cream (0.1% nortriptyline HCl +0.3% loratadine); CRx-197 low dose topical cream (0.1% nortriptyline HCl + 0.1% loratadine); Nortriptyline/loratadine - Zalicus

Latest Information Update: 29 Mar 2011

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At a glance

  • Originator CombinatoRx
  • Developer Zalicus
  • Class Anti-inflammatories; Antiallergics; Dibenzocycloheptenes; Piperidines; Skin disorder therapies; Tricyclic antidepressants
  • Mechanism of Action Cytokine modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.


Highest Development Phases

  • Discontinued Plaque psoriasis

Most Recent Events

  • 31 Dec 2010 Discontinued - Phase-II for Plaque psoriasis in Germany (Topical)
  • 09 Sep 2010 CombinatoRx is now called Zalicus
  • 14 Jan 2009 CombinatoRx completes a phase II trial for Plaque psoriasis in Germany (NCT00796211)
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