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Vemurafenib - Roche

Drug Profile

Vemurafenib - Roche

Alternative Names: PLX-4032; R-7204; RG-7204; RO-5185426; Zelboraf

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator Plexxikon
  • Developer Chugai Pharmaceutical; Genentech; Georgetown University; H. Lee Moffitt Cancer Center and Research Institute; M. D. Anderson Cancer Center; Melanoma Research Alliance; Memorial Sloan-Kettering Cancer Center; Plexxikon; Roche; University College London; University Hospital Tubingen
  • Class 2 ring heterocyclic compounds; Antineoplastics; Chlorobenzenes; Fluorobenzenes; Pyridines; Pyrroles; Small molecules; Sulfonamides
  • Mechanism of Action Proto oncogene protein b raf inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Malignant melanoma
  • Registered Immunological disorders
  • Phase II Brain metastases; Colorectal cancer; Haematological malignancies; Multiple myeloma; Non-small cell lung cancer; Solid tumours; Thyroid cancer

Most Recent Events

  • 01 Sep 2018 The University of Iowa and Genentech terminates a phase I/II trial for Malignant melanoma (Combination therapy, Second-line therapy or greater, Metastatic disease) in USA (NCT01876641)
  • 31 Jul 2018 Phase-II clinical trials in Brain metastases (Combination therapy, Metastatic disease, Second-line therapy or greater) in Spain (PO) (EudraCT2018-000759-41)
  • 24 Jun 2018 Biomarkers information updated
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