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Research programme: anti-infectives - Emergent BioSolutions

Drug Profile

Research programme: anti-infectives - Emergent BioSolutions

Alternative Names: 2-pyridone based topoisomerase inhibitors (EV-035); EBX 205; EV 035 series - Emergent BioSolutions; EV-021; EV-035; EV-035a; EV-035b; EV-035c; EV-075; EV-086; GC-0146; GC-061; GC-063; GC-072

Latest Information Update: 19 Jul 2018

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At a glance

  • Originator Evolva Biotech
  • Developer Emergent BioSolutions; United States Army Research Laboratory
  • Class Antibacterials; Pyridones; Small molecules
  • Mechanism of Action Immunomodulators; Type II bacterial DNA topoisomerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Anthrax; Burkholderia infections; Methicillin-resistant Staphylococcus aureus infections; Skin and soft tissue infections
  • Discontinued Ebola virus infections; Escherichia coli infections; Influenza virus infections; Mycoses

Most Recent Events

  • 14 Jul 2018 Antimicrobial data from in vitro studies in Public health threats presented at ASM Microbe (ASMM - 2018)
  • 04 Jun 2018 Preclinical development in Bacterial infections, Methicillin-resistant Staphylococcus aureus infections, Anthrax and Burkholderia infections is ongoing in USA (PO) (Emergent Biosciences pipeline, June 2018)
  • 04 Jun 2018 Discontinued - Preclinical for Escherichia coli infections in Switzerland (PO)
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