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Etirinotecan pegol - Nektar Therapeutics

Drug Profile

Etirinotecan pegol - Nektar Therapeutics

Alternative Names: Irinotecan - Nektar Therapeutics; NKTR-102; ONZEALD; PEG-Irinotecan; Pegylated irinotecan - Nektar Therapeutics

Latest Information Update: 25 Sep 2018

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At a glance

  • Originator Nektar Therapeutics
  • Developer Clovis Oncology; Mayo Clinic; Nektar Therapeutics; Roswell Park Cancer Institute; Stanford University School of Medicine; University of Pennsylvania Cancer Center
  • Class Alkaloids; Antineoplastics; Camptothecins; Heterocyclic compounds with 4 or more rings; Indolizines; Piperidines; Polyethylene glycols; Quinolines
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity No

Highest Development Phases

  • Preregistration Breast cancer
  • Phase II Colorectal cancer; Glioma; Non-small cell lung cancer; Ovarian cancer; Small cell lung cancer
  • No development reported Cervical cancer; Solid tumours

Most Recent Events

  • 19 Sep 2018 Pharmacodynamics data from a phase III BEACON trial in Breast cancer released by ApoCell
  • 24 Jun 2018 Biomarkers information updated
  • 04 Feb 2018 Daiichi Sankyo Europe terminates its licence for etirinotecan pegol in Europe, Switzerland and Turkey
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