Sembragiline
Alternative Names: EVT-302; RG-1577; RO-4602522Latest Information Update: 05 Nov 2023
At a glance
- Originator Roche
- Developer Evotec SE; Roche
- Class Acetanilides; Nootropics; Pyrrolidines; Small molecules; Smoking cessation therapies
- Mechanism of Action Monoamine oxidase B inhibitors
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Phase II Alzheimer's disease
- Discontinued Smoking withdrawal
Most Recent Events
- 08 Sep 2016 Phase II development is ongoing in Australia, Canada, Czech Republic, France, Germany, Italy, Poland, South Korea, Spain, Sweden, United Kingdom and USA (Evotec pipeline, September 2016)
- 30 Jun 2015 Interim efficacy and safety data from a phase-II trial in Alzheimer's disease released by Roche (NCT01677754)
- 22 Jun 2015 No recent reports on development identified - Phase-I for Alzheimer's disease (In volunteers) in Netherlands (PO)