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Drug Profile


Alternative Names: EVT-302; RG-1577; RO-4602522

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator Roche
  • Developer Evotec SE; Roche
  • Class Acetanilides; Nootropics; Pyrrolidines; Small molecules; Smoking cessation therapies
  • Mechanism of Action Monoamine oxidase B inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alzheimer's disease
  • Discontinued Smoking withdrawal

Most Recent Events

  • 08 Sep 2016 Phase II development is ongoing in Australia, Canada, Czech Republic, France, Germany, Italy, Poland, South Korea, Spain, Sweden, United Kingdom and USA (Evotec pipeline, September 2016)
  • 30 Jun 2015 Interim efficacy and safety data from a phase-II trial in Alzheimer's disease released by Roche (NCT01677754)
  • 22 Jun 2015 No recent reports on development identified - Phase-I for Alzheimer's disease (In volunteers) in Netherlands (PO)
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