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Etrolizumab - Genentech

Drug Profile

Etrolizumab - Genentech

Alternative Names: Monoclonal antibody beta7; PRO145223; recombinant-human-monoclonal-antibody-beta7; RG 7413; rhu-monoclonal-antibody-beta7; rhuMAb Beta7; rhuMAb β7; RO 5490261

Latest Information Update: 21 Dec 2018

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At a glance

  • Originator Genentech
  • Developer Genentech; Roche
  • Class Antiulcers; Bispecific antibodies; Monoclonal antibodies
  • Mechanism of Action Alpha4beta7 integrin antagonists; Integrin alphaEbeta7 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Crohn's disease; Ulcerative colitis

Most Recent Events

  • 20 Oct 2018 Preliminary efficacy data from the phase III BERGAMOT trial in Crohn's-disease presented at the 26th United European Gastroenterology Week (UEGK-2018)
  • 09 Apr 2018 Genentech completes a phase I trial in Healthy volunteers in USA (SC) (NCT02996019)
  • 13 Mar 2018 Phase-I clinical trials in Crohn's disease (In children, In adolescents) in Spain, Poland (SC) (NCT03478956) (EudraCT2017-003649-10)
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