Dactolisib - resTORbio

Drug Profile

Dactolisib - resTORbio

Alternative Names: BEZ-235; Dactolisib-tosylate; NVP-BEZ-235; NVP-BEZ235-ANA; NVP-BEZ235-NX; RTB-101

Latest Information Update: 19 Nov 2018

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At a glance

  • Originator Novartis
  • Developer Memorial Sloan-Kettering Cancer Center; Novartis; resTORbio
  • Class 3-ring heterocyclic compounds; Acetonitriles; Antineoplastics; Antivirals; Benzenesulfonates; Imidazoles; Nitriles; Quinolines; Small molecules
  • Mechanism of Action 1 Phosphatidylinositol 3 kinase inhibitors; 3 phosphoinositide dependent protein kinase 1 inhibitors; Apoptosis stimulants; Immunostimulants; MTOR protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Influenza virus infections; Respiratory tract infections
  • Discontinued Breast cancer; Glioblastoma; Haematological malignancies; Non-small cell lung cancer; Pancreatic cancer; Perivascular epithelioid cell tumours; Prostate cancer; Renal cell carcinoma; Solid tumours

Most Recent Events

  • 13 Nov 2018 resTORbio plans an end-of-phase II meeting with the US FDA for Respiratory tract infections, in the first quarter of 2019
  • 16 Oct 2018 Additional efficacy data from a phase IIb trial in Respiratory tract infections released by resTORbio
  • 16 Oct 2018 resTORbio plans a pivotal phase III program for Respiratory tract infections in first half of 2019
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