XL 281

Drug Profile

XL 281

Alternative Names: BMS-908662; XL-281

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Exelixis
  • Developer Bristol-Myers Squibb; Exelixis
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Raf kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Colorectal cancer; Malignant melanoma

Most Recent Events

  • 11 Jun 2013 Bristol-Myers Squibb completes a phase I trial in Malignant melanoma in USA (NCT01245556)
  • 31 Oct 2011 XL 281 is no longer licensed to Bristol-Myers Squibb
  • 29 Sep 2011 Bristol-Myers Squibb completes a phase I/II trial in Colorectal cancer (metastatic disease, in combination with cetuximab) in US and Canada (NCT01086267)
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