Pevonedistat - Takeda Oncology

Drug Profile

Pevonedistat - Takeda Oncology

Alternative Names: MLN-4924; MLN4924-003; Pevonedistat hydrochloride; TAK 924

Latest Information Update: 07 Aug 2018

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At a glance

  • Originator Millennium Pharmaceuticals
  • Developer Children's Oncology Group; Memorial Sloan-Kettering Cancer Center; National Cancer Institute (USA); Takeda Oncology; University of Miami; University of Michigan Comprehensive Cancer Center; University of Southern California; University of Texas M. D. Anderson Cancer Center; Vanderbilt-Ingram Cancer Center; Washington University School of Medicine
  • Class 2 ring heterocyclic compounds; Amines; Antineoplastics; Cyclopentanes; Indenes; Pyrimidines; Pyrroles; Small molecules; Sulfonic acids
  • Mechanism of Action NEDD 8 activating enzyme inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia; Myelodysplastic syndromes
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia; Chronic myelomonocytic leukaemia; Myelodysplastic syndromes
  • Phase II Myeloproliferative disorders; Non-small cell lung cancer
  • Phase I/II Mesothelioma
  • Phase I Lymphoma; Myelofibrosis; Precursor cell lymphoblastic leukaemia-lymphoma; Solid tumours

Most Recent Events

  • 14 Jun 2018 Adverse events and efficacy data from a phase I trial in Acute myeloid leukaemia and Myelodysplastic syndromes presented at the 23rd Congress of the European Haematology Association (EHA-2018)
  • 12 Jun 2018 Phase-I clinical trials in Precursor cell lymphoblastic leukaemia-lymphoma (Combination therapy, In adolescents, In adults, Second-line therapy or greater) in USA (IV) (NCT03349281)
  • 21 May 2018 Millennium Pharmaceuticals completes a phase Ib trial for Solid tumours (Combination therapy, Metastatic disease, Late stage disease) in USA (NCT01862328)
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