Dinaciclib - Merck & Co

Drug Profile

Dinaciclib - Merck & Co

Alternative Names: MK-7965; PS-095760; SCH 727965; SCHOOL 727965

Latest Information Update: 13 Aug 2018

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At a glance

  • Originator Pharmacopeia
  • Developer AbbVie; Merck & Co; University of California at San Francisco
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Apoptosis stimulants; CDC2 protein kinase inhibitors; Cyclin dependent kinase 9 inhibitors; Cyclin-dependent kinase 2 inhibitors; Cyclin-dependent kinase 5 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Chronic lymphocytic leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Chronic lymphocytic leukaemia
  • Phase I Acute myeloid leukaemia; Breast cancer; Haematological malignancies
  • No development reported Non-small cell lung cancer
  • Discontinued Leukaemia; Mantle-cell lymphoma

Most Recent Events

  • 23 Jul 2018 Phase-I clinical trials in Acute myeloid leukaemia (Combination therapy, Second-line therapy or greater) in Spain (IV) (NCT03484520)
  • 06 Apr 2018 AbbVie in collaboration with Merck Sharp & Dohme plans a phase Ib trial in Acute myeloid leukaemia (Second-line therapy or greater, Combination therapy) in USA and Australia, in June 2018 (NCT03484520)
  • 27 Jan 2017 Merck terminates a phase III trial in Chronic lymphocytic leukaemia (Second-line therapy or greater) due to program prioritisation and some safety or efficacy issues in USA, Belgium, Italy, Poland, Czech Republic, Sweden, Finland, Hungary, Lithuania, Latvia, Estonia, Spain, Greece, Norway and Slovakia
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