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Osilodrostat - Recordati

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Drug Profile

Osilodrostat - Recordati

Alternative Names: Isturisa; LCI-699

Latest Information Update: 05 Feb 2026

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At a glance

  • Originator Novartis
  • Developer Novartis; Recordati
  • Class Antihypertensives; Antineoplastics; Antisecretories; Corticosteroids; Fluorobenzenes; Heart failure therapies; Imidazoles; Nitriles; Pyridines; Pyrrolidines; Small molecules
  • Mechanism of Action Cytochrome P-450 CYP11B2 inhibitors; Steroid 11-beta-hydroxylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pituitary ACTH hypersecretion; Cushing syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Cushing syndrome; Pituitary ACTH hypersecretion
  • Discontinued Heart failure; Hypertension; Solid tumours

Most Recent Events

  • 13 Jan 2026 Launched for Cushing syndrome in Canada (PO)
  • 29 Jul 2025 Registered for Cushing syndrome in Canada (PO), prior to July 2025
  • 29 Jul 2025 Registered for Cushing syndrome in Russia (PO), prior to July 2025

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