Osilodrostat - Novartis

Drug Profile

Osilodrostat - Novartis

Alternative Names: LCI-699

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Novartis
  • Class Antihypertensives; Fluorobenzenes; Imidazoles; Nitriles; Pyridines; Small molecules
  • Mechanism of Action Aldosterone synthase inhibitors; Steroid 11-beta-hydroxylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Pituitary ACTH hypersecretion
  • Phase II Cushing syndrome
  • Discontinued Heart failure; Hypertension; Solid tumours

Most Recent Events

  • 22 Feb 2018 Novartis announces intention to submit regulatory applications for Pituitary ACTH hypersecretion in 2018 (Novartis pipeline, February 2018)
  • 01 Apr 2017 Efficacy and adverse events data from phase II trials in Cushing's syndrome presented at the 99th Annual Meeting of the Endocrine Society (ENDO-2017)
  • 15 Dec 2016 Biomarkers information updated
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