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Linsitinib - Sling Therapeutics

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Drug Profile

Linsitinib - Sling Therapeutics

Alternative Names: ASP-7487; Linsitinib - Astellas Pharma; OSI-906; OSI-906AA

Latest Information Update: 24 Jan 2025

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At a glance

  • Originator OSI Pharmaceuticals
  • Developer Astellas Pharma; Multiple Myeloma Research Foundation; Sling Therapeutics
  • Class Cyclobutanes; Imidazoles; Pyrazines; Quinolines; Small molecules
  • Mechanism of Action IGF type 1 receptor antagonists; Insulin receptor antagonists; Protein tyrosine kinase inhibitors; Receptor protein-tyrosine kinase antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Adrenocortical carcinoma
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II/III Graves ophthalmopathy
  • Preclinical Autoimmune disorders; Unspecified
  • Discontinued Adrenocortical carcinoma; Liver cancer; Multiple myeloma; Non-small cell lung cancer; Ovarian cancer

Most Recent Events

  • 14 Jan 2025 Efficacy and adverse events data from a phase IIb/III LIDS trial in Graves ophthalmology released by Sling Therapeutics
  • 14 Jan 2025 Sling Therapeutics plans a phase III confirmatory trial for Graves ophthalmology (PO) in 2025
  • 01 Jun 2024 Pharmacodynamics data from preclinical trial in Graves ophthalmopathy presented at the 106th Annual Meeting of the Endocrine Society (ENDO-2024)

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