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Linsitinib - Astellas

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Drug Profile

Linsitinib - Astellas

Alternative Names: ASP-7487; OSI-906; OSI-906AA

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator OSI Pharmaceuticals
  • Developer Astellas Pharma; Multiple Myeloma Research Foundation
  • Class Cyclobutanes; Imidazoles; Pyrazines; Quinolines; Small molecules
  • Mechanism of Action Insulin receptor antagonists; Insulin-like growth factor-I receptor antagonists; Protein tyrosine kinase inhibitors; Receptor protein-tyrosine kinase antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Adrenocortical carcinoma
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Adrenocortical carcinoma; Liver cancer; Multiple myeloma; Non-small cell lung cancer; Ovarian cancer

Most Recent Events

  • 24 Jun 2018 Biomarkers information updated
  • 27 Dec 2017 Discontinued - Phase-I/II for Multiple myeloma (Combination therapy, Second-line therapy or greater) in Canada, USA (PO) (NCT01672736)
  • 27 Dec 2017 Astellas and MMRF terminates a phase I/II trial for Multiple myeloma in USA and Canada as the sponsor decided to stop further manufacture of the study drug (PO) (NCT01672736)
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