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Ampreloxetine - Zymeworks

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Drug Profile

Ampreloxetine - Zymeworks

Alternative Names: Ampreloxetine; Ampreloxetine hydrochloride; TD 9855; TD-9855 HCl

Latest Information Update: 25 Sep 2026

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At a glance

  • Originator Theravance
  • Developer Theravance Biopharma
  • Class Analgesics; Antihypotensives; Behavioural disorder therapies; Piperidines; Small molecules
  • Mechanism of Action Adrenergic uptake inhibitors; Central nervous system stimulants; Serotonin uptake inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Orthostatic hypotension
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Discontinued Attention-deficit hyperactivity disorder; Fibromyalgia; Orthostatic hypotension

Most Recent Events

  • 24 Sep 2026 Theravance Biopharma has been acquired and merged into Zymeworks
  • 03 Mar 2026 Discontinued - Phase-III for Orthostatic hypotension (In adults, In the elderly) in Argentina (PO)
  • 03 Mar 2026 Discontinued - Phase-III for Orthostatic hypotension (In adults, In the elderly) in Austria (PO)

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