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Caplacizumab - Ablynx

Drug Profile

Caplacizumab - Ablynx

Alternative Names: ALX-0081; ALX-0681; Anti-von Willebrand factor Nanobody® - Ablynx; Cablivi

Latest Information Update: 12 Feb 2019

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At a glance

  • Originator Ablynx
  • Class Anticoagulants; Antithrombotics; Monoclonal antibodies; Proteins; Recombinant proteins; Single-domain antibodies
  • Mechanism of Action Platelet aggregation inhibitors; Von Willebrand factor inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Thrombotic thrombocytopenic purpura
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Marketed Thrombotic thrombocytopenic purpura
  • Discontinued Thrombosis

Most Recent Events

  • 08 Feb 2019 Registered for Thrombotic thrombocytopenic purpura (Adjunctive treatment) in USA (IV)
  • 06 Feb 2019 Registered for Thrombotic thrombocytopenic purpura (Adjunctive treatment) in USA (SC)
  • 01 Dec 2018 Posthoc safety data from the phase III HERCULES trial in Thrombotic thrombocytopenic purpura presented at the 60th Annual Meeting and Exposition of the American Society of Hematology (ASH-2018)
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