Caplacizumab - Ablynx

Drug Profile

Caplacizumab - Ablynx

Alternative Names: ALX-0081; ALX-0681; Anti-von Willebrand factor Nanobody® - Ablynx; Cablivi

Latest Information Update: 13 Jul 2018

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At a glance

  • Originator Ablynx
  • Class Anticoagulants; Antithrombotics; Monoclonal antibodies; Proteins; Recombinant proteins; Single-domain antibodies
  • Mechanism of Action Platelet aggregation inhibitors; Von Willebrand factor inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Thrombotic thrombocytopenic purpura
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Thrombotic thrombocytopenic purpura
  • Discontinued Thrombosis

Most Recent Events

  • 29 Jun 2018 Ablynx and Sanofi announce intention to submit BLA to the US FDA for Thrombotic thrombocytopenic purpura in the first half of 2018
  • 29 Jun 2018 The Committee for Medicinal Products for Human Use (CHMP) issued a positive opinion and recommended approval of caplacizumab (Cablivi™) for the treatment of acquired thrombotic thrombocytopenic purpura
  • 19 Jun 2018 Ablynx has been acquired by Sanofi
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