Research programme: cancer immunotherapies - Asterias Biotherapeutics

Drug Profile

Research programme: cancer immunotherapies - Asterias Biotherapeutics

Alternative Names: Antigen-presenting allogeneic dendritic cells; AST-VAC2; AST-VAC2 allogeneic dendritic cell cancer vaccine - Asterias Biotherapeutics; GRNVAC 2; VAC 2

Latest Information Update: 20 Feb 2018

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At a glance

  • Originator Geron Corporation
  • Developer Asterias Biotherapeutics; Cancer Research UK
  • Class Cell therapies; Dendritic cell vaccines
  • Mechanism of Action Cell replacements; Immunomodulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Preclinical Lung cancer
  • Discontinued Transplant rejection

Most Recent Events

  • 15 Feb 2018 Asterias Biotherapeutics has patent protection for its AST-VAC2 programme in the US, Europe, Japan, Canada, China, Australia, Israel and South Korea
  • 04 Jan 2018 Asterias and Cancer Research UK plan to conduct a phase I/IIa trial in Non-small cell lung cancer (Early-stage disease, Late stage disease, Metastatic disease, Second-line therapy or greater) in the second quarter of 2018 (NCT03371485)
  • 26 Sep 2017 Asterias Biotherapeutics receives regulatory approval from the Medicines and Healthcare Products Regulatory Agency (MHRA) and the NHS Research Ethics Committee (REC) for the conduction of a phase I/IIa trial in Non-small cell lung cancer in United Kingdom
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