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Ruxolitinib - Incyte Corporation/Novartis

Drug Profile

Ruxolitinib - Incyte Corporation/Novartis

Alternative Names: INC-424; INCB 018424 phosphate; INCB-018424; INCB-18424; Jakafi; Jakavi; Opzelura; RUX; ruxolitinib phosphate

Latest Information Update: 02 May 2024

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At a glance

  • Originator Incyte Corporation
  • Developer Baylor Breast Care Center; CMS Medical; Dana-Farber Cancer Institute; H. Lee Moffitt Cancer Center and Research Institute; Incyte Corporation; Lymphoma Academic Research Organisation; National Cancer Institute (USA); Novartis; RWTH Aachen University; University Health Network of Toronto; University of Cologne; University of Rochester; University of Texas M. D. Anderson Cancer Center; Washington University School of Medicine
  • Class 2 ring heterocyclic compounds; Anti-inflammatories; Antianaemics; Antibronchitics; Antihaemorrhagics; Antineoplastics; Antipsoriatics; Antirheumatics; Antivirals; Cyclopentanes; Nitriles; Pyrazoles; Pyrimidines; Pyrroles; Skin disorder therapies; Small molecules
  • Mechanism of Action Janus kinase 1 inhibitors; Janus kinase-2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myelofibrosis; Pancreatic cancer; Polycythaemia vera; Essential thrombocythaemia; Precursor cell lymphoblastic leukaemia-lymphoma; Graft-versus-host disease
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Atopic dermatitis; Graft-versus-host disease; Myelofibrosis; Polycythaemia vera; Vitiligo
  • Phase III Cytokine release syndrome; Essential thrombocythaemia; Prurigo nodularis; SARS-CoV-2 acute respiratory disease
  • Phase II/III COVID-19 pneumonia
  • Phase II Acute myeloid leukaemia; Alopecia areata; Breast cancer; Breast disorders; Bronchiolitis obliterans; Cachexia; Chronic lymphocytic leukaemia; Chronic myeloid leukaemia; Chronic myelomonocytic leukaemia; Discoid lupus erythematosus; Haematological malignancies; Head and neck cancer; Hidradenitis suppurativa; HIV infections; Hodgkin's disease; Lichen planus; Myelodysplastic syndromes; Precursor cell lymphoblastic leukaemia-lymphoma; Thalassaemia; Vulvar lichen sclerosus
  • Phase I/II Anaemia; HER2 positive breast cancer; Multiple myeloma
  • Phase I Adenocarcinoma
  • No development reported Psoriasis
  • Discontinued Colorectal cancer; HER2 negative breast cancer; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer; Rheumatoid arthritis

Most Recent Events

  • 30 Apr 2024 Registered for Graft-versus-host disease in USA (PO) (Incyte corporation pipeline, April 2024)
  • 19 Apr 2024 Phase-III clinical trials in Atopic dermatitis (Treatment-experienced) in USA (Topical) (NCT06238817)
  • 08 Apr 2024 Incyte Corporation completes a phase III clinical trial in Atopic dermatitis (In children) in USA and Canada (Topical) (NCT04921969)
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