Alvelestat - AstraZeneca/Mereo BioPharma

Drug Profile

Alvelestat - AstraZeneca/Mereo BioPharma

Alternative Names: AZD-9668

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator AstraZeneca
  • Developer Allegheny Singer Research Institute; AstraZeneca; National Cancer Institute (USA)
  • Class Amides; Bronchodilators; Pyrazoles; Pyridines
  • Mechanism of Action Leucocyte elastase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Type 2 diabetes mellitus
  • Phase I/II Bronchiolitis obliterans
  • Discontinued Bronchiectasis; Chronic obstructive pulmonary disease; Cystic fibrosis

Most Recent Events

  • 20 Nov 2017 Chemical structure added
  • 30 Oct 2017 Mereo Biopharma plans a phase II trial for Alpha-1 antitrypsin deficiency (PO) in 2018
  • 30 Oct 2017 Alvelestat is licensed to Mereo BioPharma
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