Alvelestat - AstraZeneca/Mereo BioPharma

Drug Profile

Alvelestat - AstraZeneca/Mereo BioPharma

Alternative Names: AZD-9668; MPH-966

Latest Information Update: 16 Aug 2018

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At a glance

  • Originator AstraZeneca
  • Developer Allegheny Singer Research Institute; AstraZeneca; Mereo BioPharma; National Cancer Institute (USA)
  • Class Amides; Anti-inflammatories; Antibronchitics; Antihyperglycaemics; Pyrazoles; Pyridines
  • Mechanism of Action Leucocyte elastase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alpha 1-antitrypsin deficiency; Type 2 diabetes mellitus
  • Phase I/II Bronchiolitis obliterans
  • Discontinued Bronchiectasis; Chronic obstructive pulmonary disease; Cystic fibrosis

Most Recent Events

  • 25 Sep 2018 Mereo BioPharma plans the phase II ATALANTa trial for Alpha 1-antitrypsin deficiency in USA (PO, Tablet) (NCT03679598)
  • 08 Aug 2018 Phase-II clinical trials in Alpha 1-antitrypsin deficiency in European Union, USA (PO)
  • 24 Jun 2018 Biomarkers information updated
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