Drug Profile


Alternative Names: AUY-922; NVP-AUY-922; VER-52296

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Cancer Research Technology; The Institute of Cancer Research; Vernalis
  • Developer Memorial Sloan-Kettering Cancer Center; Novartis; Royal Marsden NHS Foundation Trust; Sarah Cannon Research Institute; SCRI Development Innovations; The Institute of Cancer Research; University of Texas M. D. Anderson Cancer Center; University of Toronto; Vernalis
  • Class Amides; Antineoplastics; Isoxazoles; Morpholines; Resorcinols; Small molecules
  • Mechanism of Action HSP90 heat-shock protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Preclinical Head and neck cancer
  • Suspended Breast cancer; Colorectal cancer; Gastric cancer; Gastrointestinal stromal tumours; Lymphoma; Multiple myeloma; Myeloproliferative disorders; Non-small cell lung cancer; Solid tumours
  • Discontinued Pancreatic cancer

Most Recent Events

  • 25 Apr 2017 Preclinical trials in Head and neck cancer in USA (Parenteral)
  • 22 Jan 2017 M.D. Anderson Cancer Center and Novartis terminates a phase II trial due to limited response for Lymphoma (Second-line therapy or greater) in USA (NCT01485536)
  • 01 Jan 2017 Novartis terminates a phase II trial in Non-small-cell lung cancer (Metastatic disease, Late-stage disease, Recurrent, Second-line therapy or greater) due to futility data in USA, United Kingdom, Australia, France, Hong Kong, Israel, Italy, Japan, Netherlands, Norway, Poland, Singapore, South Korea, Spain, and Taiwan (NCT01646125)
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