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CRS 3123

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Drug Profile

CRS 3123

Alternative Names: CRS3123; REP 3123

Latest Information Update: 23 Jun 2025

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At a glance

  • Originator Replidyne
  • Developer Crestone; National Institute of Allergy and Infectious Diseases
  • Class Amines; Antibacterials; Chromans; Halogenated hydrocarbons; Pyridines; Pyridones; Small molecules
  • Mechanism of Action Methionine tRNA ligase inhibitors; Protein synthesis inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Clostridium difficile infections

Most Recent Events

  • 15 Jun 2025 Crestone completes a phase I trial (In volunteers) in USA (PO, Capsule) (NCT06988423)
  • 09 May 2025 Crestone initiates enrolment in a phase I trial (In volunteers) in USA (PO, Capsule) (NCT06988423)
  • 09 Sep 2024 Adverse events and efficacy data from a phase II trial in Clostridium difficile infections released by Crestone

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