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Refametinib

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Drug Profile

Refametinib

Alternative Names: AR-119; BAY-86-9766; RDEA-119; VRX-119

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator Valeant Pharmaceuticals International
  • Developer Ardea Biosciences; Bayer HealthCare; Samsung Medical Center
  • Class Aniline compounds; Anti-inflammatories; Antineoplastics; Small molecules; Sulfonamides
  • Mechanism of Action Mitogen-activated protein kinase kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Liver cancer
  • Phase I/II Pancreatic cancer; Solid tumours
  • Discontinued Biliary cancer; Inflammation

Most Recent Events

  • 28 Dec 2022 Discontinued - Phase-II for Liver cancer (Combination therapy, First-line therapy, Inoperable/Unresectable, Metastatic disease) in Thailand, Turkey, Taiwan, Switzerland, United Kingdom, New Zealand, Singapore, Japan, Spain, South Korea, China, Belgium, Austria, Czech Republic, France, Germany, Italy, Israel, Hungary, Hong Kong, USA (PO, Capsule)
  • 28 Dec 2022 Discontinued - Phase-II for Liver cancer (Combination therapy, First-line therapy, Inoperable/Unresectable, Metastatic disease) in Thailand, Turkey, Taiwan, Switzerland, United Kingdom, New Zealand, Singapore, Japan, Spain, South Korea, China, Belgium, Austria, Czech Republic, France, Germany, Italy, Israel, Hungary, Hong Kong, USA (PO, Tablet)
  • 04 Feb 2020 Discontinued - Phase-II for Biliary cancer (Inoperable/Unresectable, Metastatic disease, Second-line therapy or greater) in South Korea (PO)

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