Irinotecan sucrosofate - Ipsen

Drug Profile

Irinotecan sucrosofate - Ipsen

Alternative Names: Irinotecan liposome injection - Merrimack; MM-398; nal-IRI; Nano-irinotecan; Nanoliposomal irinotecan - Merrimack/PharmaEngine; Nanoliposomal irinotecan injection - Merrimack/PharmaEngine; Onivyde; pegylated liposomal irinotecan hydrochloride trihydrate; PEP-02; SHP-673

Latest Information Update: 22 Jun 2018

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At a glance

  • Originator HERMES BioSciences
  • Developer AIO Studien gGmbH; Emory University; Ipsen; Medica Scientia Innovation Research; Merrimack Pharmaceuticals; PharmaEngine; Shire; Taiho Pharmaceutical; University of California at San Francisco
  • Class Alkaloids; Antineoplastics; Camptothecins; Small molecules
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer
  • New Molecular Entity No

Highest Development Phases

  • Marketed Pancreatic cancer
  • Phase II/III Small cell lung cancer
  • Phase II Biliary cancer; Breast cancer; Cholangiocarcinoma; Colorectal cancer; Gallbladder cancer; Gastric cancer
  • Phase I/II Gastrointestinal cancer
  • No development reported Glioma; Solid tumours

Most Recent Events

  • 01 Jun 2018 Initial efficacy and adverse events data from a phase II trial in Pancreatic cancer presented at the 54th Annual Meeting of the American Society of Clinical Oncology (ASCO-2018)
  • 16 Apr 2018 Shire's agreement with Servier to sell its Oncology business is expected to close in the second or third quarter of 2018
  • 16 Apr 2018 Shire enters into a definitive agreement with Servier to sell its Oncology business
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