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Danegaptide - Breye Therapeutics

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Drug Profile

Danegaptide - Breye Therapeutics

Alternative Names: GAP-134; GAP-Oral; ZP 1609

Latest Information Update: 28 May 2026

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At a glance

  • Originator Zealand Pharma
  • Developer Breye Therapeutics; Wyeth; Zealand Pharma
  • Class Antiarrhythmics; Cytoprotectives; Dipeptides; Eye disorder therapies; Small molecules
  • Mechanism of Action Gap junction modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Diabetic macular oedema
  • Phase I Diabetic retinopathy
  • No development reported Wet age-related macular degeneration
  • Discontinued Atrial fibrillation; Myocardial reperfusion injury

Most Recent Events

  • 28 May 2026 No recent reports of development identified for phase-I development in Wet age-related macular degeneration in Denmark (PO)
  • 09 Feb 2026 Efficacy data from a phase Ib/IIa trial in Diabetic macular oedema released by Breye Therapeutics
  • 24 Jun 2025 Pharmacodynamics, adverse events and efficacy data from a phase Ib/IIa trial in Diabetic macular oedema released by Breye Therapeutics

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