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Quisinostat - Janssen Pharmaceutica/NewVac

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Drug Profile

Quisinostat - Janssen Pharmaceutica/NewVac

Alternative Names: JNJ-26481585

Latest Information Update: 27 May 2025

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At a glance

  • Originator Johnson & Johnson Pharmaceutical Research & Development
  • Developer Janssen Pharmaceutica; Janssen Research & Development; NewVac
  • Class Antineoplastics; Hydroxy acids; Hydroxylamines; Piperidines; Small molecules
  • Mechanism of Action Histone deacetylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Lung cancer; Ovarian cancer; Uveal melanoma
  • Preclinical Pulmonary arterial hypertension
  • No development reported Breast cancer; Sarcoma
  • Discontinued Cutaneous T-cell lymphoma; Leukaemia; Multiple myeloma; Myelodysplastic syndromes; Solid tumours

Most Recent Events

  • 08 May 2025 Phase-II clinical trials in Uveal melanoma (Second-line therapy or greater) in USA (PO) (NCT06932757)
  • 17 Apr 2025 University of Miami plans a phase II trial in Uveal Melanoma (Second-line therapy or greater) in USA (PO) in June 2025 (NCT06932757)
  • 13 Feb 2025 St. Joseph's Hospital and Medical Center plans a phase 0/Ib trial for Glioblastoma (Newly-diagnosed, Recurrent, Late-stage disease) in USA (PO), in May 2025 (NCT06824662)

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