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Denintuzumab mafodotin - Seagen

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Drug Profile

Denintuzumab mafodotin - Seagen

Alternative Names: Anti-CD19-mafodotin; Anti-CD19-mcMMAF; Anti-CD19-vcMMAE; SGN-19A; SGN-CD19A

Latest Information Update: 15 Dec 2023

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At a glance

  • Originator Seattle Genetics
  • Class Antineoplastics; Auristatins; Drug conjugates; Immunoconjugates; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Apoptosis stimulants; Immunomodulators; Mitosis inhibitors; Tubulin inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Diffuse large B cell lymphoma; Follicular lymphoma; Non-Hodgkin's lymphoma; Precursor B-cell lymphoblastic leukaemia-lymphoma

Most Recent Events

  • 14 Dec 2023 Seagen has been acquired by Pfizer
  • 08 Oct 2020 Seattle Genetics is now called Seagen
  • 26 Jul 2018 Discontinued - Phase-I for Non-Hodgkin's lymphoma (In adolescents, In children, In infants, Second-line therapy or greater, In adults) in USA (IV)

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