Drug Profile


Alternative Names: ARENEGYR; CNGRC peptide-TNF alpha conjugate; NGR-hTNF; NGR-TNFα; Tumour-homing-peptide-tumour-necrosis-factor-alpha-fusion-protein; Tumour-vasculature-targeted-tumour-necrosis-factor-alpha; Zafiride

Latest Information Update: 12 Oct 2018

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At a glance

  • Originator Scientific Institute San Raffaele
  • Developer European Organisation for Research and Treatment of Cancer; MolMed; Scientific Institute San Raffaele
  • Class Antineoplastics; Recombinant fusion proteins
  • Mechanism of Action Capillary permeability modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Liver cancer; Mesothelioma
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Mesothelioma
  • Phase II Colorectal cancer; Liver cancer; Non-Hodgkin's lymphoma; Non-small cell lung cancer; Ovarian cancer; Small cell lung cancer; Soft tissue sarcoma
  • No development reported Solid tumours

Most Recent Events

  • 28 Sep 2018 No recent reports of development identified for phase-I development in Solid-tumours(Late-stage disease, Metastatic disease, Monotherapy, Second-line therapy or greater) in Italy (IV, Infusion)
  • 24 Jun 2018 Biomarkers information updated
  • 04 Jun 2018 Efficacy and safety data from a phase II INGRID trial in Non-Hodgkin's lymphoma released by MolMed
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