Drug Profile


Alternative Names: ARENEGYR; CNGRC peptide-TNF alpha conjugate; NGR-hTNF; NGR-TNFα; Zafiride

Latest Information Update: 07 Jun 2018

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At a glance

  • Originator Scientific Institute San Raffaele
  • Developer European Organisation for Research and Treatment of Cancer; MolMed; Scientific Institute San Raffaele
  • Class Antineoplastics; Recombinant fusion proteins
  • Mechanism of Action Capillary permeability modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hepatocellular carcinoma; Mesothelioma
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Mesothelioma
  • Phase II Colorectal cancer; Hepatocellular carcinoma; Non-Hodgkin's lymphoma; Non-small cell lung cancer; Ovarian cancer; Small cell lung cancer; Soft tissue sarcoma
  • No development reported Solid tumours

Most Recent Events

  • 04 Jun 2018 Efficacy and safety data from a phase II INGRID trial in Non-Hodgkin's lymphoma released by MolMed
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Solid-tumours(Combination therapy) in Italy (IV, Infusion)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Solid-tumours(Combination therapy, Late-stage disease) in Italy (IV, Infusion)
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