Voxtalisib - Exelixis/ Sanofi

Drug Profile

Voxtalisib - Exelixis/ Sanofi

Alternative Names: SAR-245409; XL-765

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Exelixis
  • Developer EMD Serono; Exelixis; Sanofi
  • Class Antineoplastics; Pyrazoles; Pyridones; Pyrimidines; Small molecules
  • Mechanism of Action 1 Phosphatidylinositol 3 kinase inhibitors; MTOR protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours
  • No development reported Chronic lymphocytic leukaemia; Glioblastoma; Mantle-cell lymphoma; Non-Hodgkin's lymphoma
  • Discontinued Breast cancer; Ovarian cancer

Most Recent Events

  • 30 Nov 2017 EMD Serono and Sanofi completes a phase II trial in Ovarian cancer (Inoperable/Unresectable, Second-line therapy or greater, Combination therapy) in USA, Australia, Canada, France, Poland, Italy, Belgium and Spain (PO) (NCT01936363)
  • 18 Jul 2016 Biomarkers information updated
  • 16 Jul 2016 No recent reports of development identified for phase-I development in Solid-tumours(Monotherapy) in USA (PO, Tablet)
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