Lirilumab - Bristol-Myers Squibb/Innate Pharma

Drug Profile

Lirilumab - Bristol-Myers Squibb/Innate Pharma

Alternative Names: Anti-KIR (1-7F9); Anti-KIR monoclonal antibody - Innate Pharma; BMS-986015; IPH-21; IPH-2101; IPH-2102; NN 1975; ONO-4483

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Novo Nordisk
  • Developer Bristol-Myers Squibb; Innate Pharma; National Cancer Institute (USA); Ono Pharmaceutical; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action KIR receptor antagonists; Natural killer cell stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Chronic lymphocytic leukaemia; Myelodysplastic syndromes
  • Phase I/II Solid tumours
  • Phase I Haematological malignancies; Multiple myeloma
  • Preclinical Lymphoma
  • Discontinued Acute myeloid leukaemia; Hepatitis C

Most Recent Events

  • 13 Feb 2018 Bristol-Myers Squibb initiates enrolment in the phase I ADVISE trial for Solid tumours (Late-stage disease, Combination therapy, Second-line therapy or greater) in USA (IV) (NCT03335540)
  • 21 Nov 2017 Dana-Farber Cancer Institute and Bristol-Myers Squibb plan a phase II trial for Head and neck cancer (Recurrent, Combination therapy) in USA in December 2017 (NCT03341936)
  • 10 Oct 2017 Bristol-Myers Squibb completes a phase I trial in Multiple myeloma (Combination therapy, Second-line therapy or greater) in USA, Spain (IV) (NCT02252263)
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