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Drug Profile


Alternative Names: COTI-2

Latest Information Update: 13 Nov 2018

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At a glance

  • Originator Critical Outcome Technologies
  • Developer Cotinga Pharmaceuticals; Northwestern University; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Apoptosis stimulants; Cyclin-dependent kinase modulators; Iron chelating agents; Methylenetetrahydrofolate reductase modulators; P53 gene modulators; Protein kinase inhibitors; Proto oncogene protein c-akt inhibitors; Thymidylate synthase modulators; Tubulin modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I/II Cancer
  • Phase I Cervical cancer; Endometrial cancer; Fallopian tube cancer; Head and neck cancer; Ovarian cancer; Peritoneal cancer
  • Preclinical Acute myeloid leukaemia; Li-Fraumeni syndrome
  • No development reported Colorectal cancer

Most Recent Events

  • 05 Nov 2018 Cotinga Pharmaceuticals and St Vincents University Hospital agree to co-develop COTI 2 for Breast cancer
  • 05 Nov 2018 Cotinga Pharmaceuticals and St Vincents university Hospital plans a phase I trial for Breast cancer (Combination therapy, Second-line therapy or greater, Metastatic disease)
  • 29 Aug 2018 Cotinga Pharmaceuticals plans a p53 basket trial in Solid tumours including breast cancer
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