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Liafensine - Denovo Biopharma

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Drug Profile

Liafensine - Denovo Biopharma

Alternative Names: BMS-820836; DB 104

Latest Information Update: 28 Jan 2026

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At a glance

  • Originator AMRI
  • Developer Bristol-Myers Squibb; Denovo Biopharma
  • Class Antidepressants; Isoquinolines; Naphthalenes; Pyridazines; Small molecules; Tetrahydroisoquinolines
  • Mechanism of Action Adrenergic receptor antagonists; Dopamine uptake inhibitors; Serotonin uptake inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Depressive disorders
  • No development reported Major depressive disorder

Most Recent Events

  • 28 Jan 2026 No recent reports of development identified for preclinical development in Major depressive disorder in USA
  • 16 Sep 2025 Denovo Biopharma plans to file NDA for Depressive disorders (Treatment-resistant)
  • 14 Aug 2025 Phase-III clinical trials in Depressive disorders (PO) prior to August 2025

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