Apabetalone - Resverlogix

Drug Profile

Apabetalone - Resverlogix

Alternative Names: RVX-000222; RVX-208

Latest Information Update: 18 Oct 2018

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At a glance

  • Originator Resverlogix Corporation
  • Class Anti-inflammatories; Cardiovascular therapies; Quinazolines; Small molecules
  • Mechanism of Action Bromodomain and extraterminal domain protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes - HIV infections

Highest Development Phases

  • Phase III Acute coronary syndromes; Atherosclerosis; Low HDL cholesterol
  • Phase II Prediabetic-state
  • Preclinical HIV infections; Renal failure
  • No development reported Alzheimer's disease

Most Recent Events

  • 01 Oct 2018 Pharmacokinetic data from in vitro studies in Diabetes presented at 54th Annual Meeting of the European Association for the Study of Diabetes (EASD-2018)
  • 05 Sep 2018 Pharmacodynamics data from the phase II ASSURE trial released by Resverlogix Corporation
  • 04 Sep 2018 NCT03655704 - added planned trial although trial is not company-sponsored, since drug is not launched (also indication is new); also added planned phase II trial from NCT record
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