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Carotuximab - Enviro Therapeutics

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Drug Profile

Carotuximab - Enviro Therapeutics

Alternative Names: Chimeric Antibody TRC105; DE-122; ENV-105; NSC#754227; TRC-105

Latest Information Update: 24 Sep 2025

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At a glance

  • Originator Roswell Park Cancer Institute
  • Developer Enviro Therapeutics; National Cancer Institute (USA); Santen Pharmaceutical; TRACON Pharmaceuticals; University of Alabama at Birmingham; University of Minnesota
  • Class Antifibrotics; Antineoplastics; Eye disorder therapies; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Angiogenesis inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Soft tissue sarcoma
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Prostate cancer
  • Phase I Non-small cell lung cancer
  • Discontinued Acute myeloid leukaemia; Breast cancer; Choriocarcinoma; Colorectal cancer; Fallopian tube cancer; Glioblastoma; Haemangiosarcoma; Liver cancer; Ovarian cancer; Peritoneal cancer; Precursor B-cell lymphoblastic leukaemia-lymphoma; Renal cell carcinoma; Soft tissue sarcoma; Wet age-related macular degeneration

Most Recent Events

  • 18 Sep 2025 Efficacy data from the phase II trial in Prostrate cancer relased by Kairos Pharma
  • 15 Jul 2025 Kairos Pharma plans to engage with regulatory agencies to discuss the design of a potential pivotal phase III trial
  • 15 Jul 2025 Adverse events data from a phase II trial in Prostate cancer released by Kairos Pharma

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