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Indoximod - NewLink Genetics Corporation

Drug Profile

Indoximod - NewLink Genetics Corporation

Alternative Names: 1 MT; 1-methyl-D-tryptophan; 1-methyltryptophan; d-1-methyltryptophan; D-1MT; NLG-8189; NSC-721782

Latest Information Update: 04 Jan 2019

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At a glance

  • Originator Lankenau Institute for Medical Research
  • Developer National Cancer Institute (USA); NewLink Genetics Corporation; University of Minnesota
  • Class Amino acids; Antineoplastics; Indoles; Small molecules
  • Mechanism of Action Indoleamine-pyrrole 2,3-dioxygenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Malignant melanoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Malignant melanoma
  • Phase II Breast cancer; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer
  • Phase I/II Glioma; Solid tumours
  • Phase I Acute myeloid leukaemia

Most Recent Events

  • 02 Dec 2018 Updated interim efficacy and adverse events data from a phase I trial in Acute myeloid leukaemia released by NewLink Genetics Corporation
  • 01 Dec 2018 Updated adverse events data from a phase I trial in Acute myeloid leukaemia presented at the 60th Annual Meeting and Exposition of the American Society of Hematology (ASH-2018)
  • 28 Nov 2018 No recent reports of development identified for phase-I development in Glioma(Combination therapy, In adolescents, In children, Second-line therapy or greater) in USA (PO, Capsule)
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