Indoximod - NewLink Genetics Corporation

Drug Profile

Indoximod - NewLink Genetics Corporation

Alternative Names: 1 MT; 1-methyl-D-tryptophan; 1-methyltryptophan; d-1-methyltryptophan; D-1MT; NLG-8189; NSC-721782

Latest Information Update: 06 Jul 2018

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At a glance

  • Originator Lankenau Institute for Medical Research
  • Developer National Cancer Institute (USA); NewLink Genetics Corporation; University of Minnesota
  • Class Amino acids; Antineoplastics; Indoles; Small molecules
  • Mechanism of Action Indoleamine-pyrrole 2,3-dioxygenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Malignant melanoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Malignant melanoma
  • Phase II Breast cancer; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer
  • Phase I/II Acute myeloid leukaemia; Glioma; Solid tumours

Most Recent Events

  • 02 Jul 2018 Efficacy and adverse events data from a phase I trial in Glioma released by NewLink Genetics
  • 04 Jun 2018 Efficacy data from a phase II trial in Malignant melanoma released by NewLink Genetics Corporation
  • 04 Jun 2018 Efficacy data from a phase II trial in Pancreatic cancer released by NewLink Genetics
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