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Indoximod - Lumos Pharma

Drug Profile

Indoximod - Lumos Pharma

Alternative Names: 1 MT; 1-methyl-D-tryptophan; 1-methyltryptophan; d-1-methyltryptophan; D-1MT; NLG-8189; NSC-721782

Latest Information Update: 31 May 2023

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At a glance

  • Originator Lankenau Institute for Medical Research
  • Developer Augusta University; Lumos Pharma; National Cancer Institute (USA); University of Minnesota
  • Class Amino acids; Antineoplastics; Indoles; Small molecules
  • Mechanism of Action Indoleamine-pyrrole 2,3-dioxygenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Malignant melanoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Malignant melanoma
  • Phase II HER2 negative breast cancer; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer
  • Phase I/II Glioma; Solid tumours
  • Phase I Brain cancer
  • No development reported Acute myeloid leukaemia

Most Recent Events

  • 14 Apr 2023 Pharmacodynamics data from phase I/II study in Cancer presented at the Annual Meeting of the American Association for Cancer Research (AACR-2023)
  • 08 Feb 2022 Phase-I clinical trials in Brain cancer (Combination therapy, In children, In adolescents, In adults, Second-line therapy or greater, Metastatic disease) in USA (PO) (NCT05106296)
  • 03 Nov 2021 Augusta University plans phase Ib trial for Brain cancer (Combination therapy, In children, In adolescents, In adults, Second line therapy or greater, Metastatic disease) in USA (PO) in February 2022 (NCT05106296)
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