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Fedratinib - Celgene Corporation

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Drug Profile

Fedratinib - Celgene Corporation

Alternative Names: FEDR; INREBIC; Inrebic; SAR-302503; TG-101348

Latest Information Update: 28 Apr 2024

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At a glance

  • Originator TargeGen
  • Developer Bristol-Myers Squibb; Celgene Corporation; Sanofi
  • Class Antifibrotics; Antihaemorrhagics; Antineoplastics; Phenyl ethers; Pyrimidines; Pyrrolidines; Small molecules; Sulfonamides
  • Mechanism of Action Fms-like tyrosine kinase 3 inhibitors; Janus kinase 2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Polycythaemia vera; Myelofibrosis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Myelofibrosis
  • Discontinued Essential thrombocythaemia; Polycythaemia vera; Solid tumours

Most Recent Events

  • 28 Apr 2024 No recent reports of development identified for phase-I development in Myelofibrosis(Combination therapy, Treatment-experienced) in Australia (PO, Capsule)
  • 10 Dec 2023 Interim efficacy and adverse events data from the phase-III FREEDOM2 trial in Myelofibrosis presented at the 65th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2023)
  • 09 Dec 2023 Pharmacodynamics data from a preclinical trial in Myelofibrosis presented at the 65th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2023)

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