Fedratinib - Celgene Corporation
Alternative Names: FEDR; INREBIC; Inrebic; SAR-302503; TG-101348Latest Information Update: 28 Apr 2024
At a glance
- Originator TargeGen
- Developer Bristol-Myers Squibb; Celgene Corporation; Sanofi
- Class Antifibrotics; Antihaemorrhagics; Antineoplastics; Phenyl ethers; Pyrimidines; Pyrrolidines; Small molecules; Sulfonamides
- Mechanism of Action Fms-like tyrosine kinase 3 inhibitors; Janus kinase-2 inhibitors
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Marketed Myelofibrosis
- Discontinued Essential thrombocythaemia; Polycythaemia vera; Solid tumours
Most Recent Events
- 28 Apr 2024 No recent reports of development identified for phase-I development in Myelofibrosis(Combination therapy, Treatment-experienced) in Australia (PO, Capsule)
- 10 Dec 2023 Interim efficacy and adverse events data from the phase-III FREEDOM2 trial in Myelofibrosis presented at the 65th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2023)
- 09 Dec 2023 Pharmacodynamics data from a preclinical trial in Myelofibrosis presented at the 65th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2023)