Lenzilumab - Humanigen
Alternative Names: Humaneered® anti-human GM-CSF monoclonal Antibody; KB-003; LENZ®Latest Information Update: 29 May 2024
At a glance
- Originator KaloBios Pharmaceuticals
- Developer Humanigen; KaloBios Pharmaceuticals; Kite Pharma; National Institute of Allergy and Infectious Diseases; Peter MacCallum Cancer Centre
- Class Anti-inflammatories; Antiallergics; Antiasthmatics; Antineoplastics; Antirheumatics; Immunotherapies; Monoclonal antibodies
- Mechanism of Action Granulocyte macrophage colony stimulating factor antagonists
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Preregistration Cytokine release syndrome
- Phase III COVID 2019 infections
- Phase II/III Graft-versus-host disease
- Phase II Chronic myelomonocytic leukaemia
- Phase I/II Drug hypersensitivity
- No development reported Precursor cell lymphoblastic leukaemia-lymphoma; Solid tumours
- Discontinued Asthma; B-cell lymphoma; Rheumatoid arthritis
Most Recent Events
- 27 Mar 2024 Humanigen completes a phase I trials in COVID-2019 infections (In volunteers) in South Korea (IV)
- 27 Mar 2024 Pharmacokinetic and adverse events data from a phase I trial in healthy volunteers presented at the 125th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT-2024)
- 03 Jan 2024 Taran Therapeutics plans to acquire lenzilumab