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Lenzilumab - Humanigen

Drug Profile

Lenzilumab - Humanigen

Alternative Names: KB-003

Latest Information Update: 04 Dec 2018

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At a glance

  • Originator KaloBios Pharmaceuticals
  • Developer Humanigen; KaloBios Pharmaceuticals
  • Class Anti-inflammatories; Antiasthmatics; Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Granulocyte macrophage colony stimulating factor antagonists; Immunomodulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Drug hypersensitivity
  • Phase I Chronic myelomonocytic leukaemia
  • Research Solid tumours
  • Discontinued Asthma; Rheumatoid arthritis

Most Recent Events

  • 30 Nov 2018 Pharmacodynamics data from preclinical xenograft study released by Humanigen
  • 30 Nov 2018 Humanigen plans a phase I/II trial for of lenzilumab in combination with CART19 therapies
  • 12 Oct 2018 Lenzilumab is still in phase I trials for Chronic myelomonocytic leukaemia in USA (NCT02546284)
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