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Sacubitril/valsartan - Novartis

Drug Profile

Sacubitril/valsartan - Novartis

Alternative Names: AHU-377/valsartan; Entresto; LCZ-696; LCZ-696A; Neparvis; Valsartan/AHU-377; Valsartan/sacubitril

Latest Information Update: 05 Feb 2020

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At a glance

  • Originator Novartis
  • Developer Novartis; Rovi
  • Class Antihypertensives; Biphenyl compounds; Branched-chain amino acids; Erectile dysfunction therapies; Esters; Heart failure therapies; Pentanoic acids; Small molecules; Tetrazoles; Urologics
  • Mechanism of Action Angiotensin type 1 receptor antagonists; Neprilysin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Marketed Essential hypertension; Heart failure
  • Phase III Erectile dysfunction; Hypertension; Kidney disorders
  • Phase II Hypertrophic cardiomyopathy

Most Recent Events

  • 08 Jan 2020 Phase-II clinical trials in Hypertrophic cardiomyopathy in Germany (PO) (EudraCT2019-003098-24)
  • 08 Jan 2020 Phase-II clinical trials in Hypertrophic cardiomyopathy in USA (PO) (NCT04164732)
  • 16 Nov 2019 Efficacy data from a phase III PARAGON-HF trial in Heart failure presented at the American Heart Association Scientific Sessions (AHA-2019)
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