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Difelikefalin - Cara Therapeutics

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Drug Profile

Difelikefalin - Cara Therapeutics

Alternative Names: CKD-943; CR-845; CR845/difelikefalin; Difelikefalin acetate - Cara Therapeutics; FE-202845; Kapruvia; KORSUVA; Korsuva; MR13A9

Latest Information Update: 24 Sep 2024

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At a glance

  • Originator Ferring Pharmaceuticals
  • Developer Cara Therapeutics; Chong Kun Dang; CSL Vifor; Kissei Pharmaceutical; Maruishi Pharmaceutical; Vifor Fresenius Medical Care Renal Pharma
  • Class Amines; Analgesics; Antipruritics; Carboxylic acids; Opioid analgesics; Peptides; Piperidines; Skin disorder therapies; Urologics
  • Mechanism of Action Opioid kappa receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes - Pain; Postoperative pain

Highest Development Phases

  • Marketed Pruritus
  • Phase III Pain; Postoperative pain

Most Recent Events

  • 19 Sep 2024 Vifor Fresenius Medical Care Renal Pharma plans a phase II trial for Pruritus (In children, In adolescents) in January 2025 (IV) (NCT06593392)
  • 12 Jun 2024 Efficacy and adverse event data from the phase II/III KOURAGE-1 trial in Pruritus (in patients with notalgia paresthetica) released by Cara Therapeutics
  • 17 May 2024 Cara Therapeutics terminates a phase-II/III trial in Pruritus (In adults, In the elderly) in Spain, Poland, Germany, Canada, USA (PO) (NCT05978063)

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