Thioureidobutyronitrile - Innovation Pharmaceuticals

Drug Profile

Thioureidobutyronitrile - Innovation Pharmaceuticals

Alternative Names: Kevetrin

Latest Information Update: 26 Oct 2018

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At a glance

  • Originator Cellceutix
  • Developer Innovation Pharmaceuticals; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Nitriles; Small molecules
  • Mechanism of Action Alkylating agents; Apoptosis stimulants; Caspase 3 stimulants; Poly(ADP-ribose) polymerase modulators; Retinoblastoma protein modulators; Tumour suppressor protein p53 stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer; Retinoblastoma; Ovarian cancer
  • New Molecular Entity Yes
  • Available For Licensing Yes - Ovarian cancer

Highest Development Phases

  • Phase II Ovarian cancer
  • Preclinical Acute myeloid leukaemia
  • No development reported Breast cancer; Chronic myeloid leukaemia; Colorectal cancer; Glioblastoma; Head and neck cancer; Lung cancer; Lymphoma; Multiple myeloma; Pancreatic cancer; Prostate cancer; Renal cancer; Retinoblastoma; Solid tumours

Most Recent Events

  • 22 Oct 2018 Innovation Pharmaceuticals plans a clinical trial for Ovarian cancer (PO)
  • 24 Jun 2018 Biomarkers information updated
  • 28 Dec 2017 Pharmacodynamics data from a phase IIa trial in Ovarian Cancer released by Innovation Pharmaceuticals
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